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Efficacy of PPIs in Upper GI Reflux

Laryngopharyngeal reflux is an inflammatory condition of the upper aerodigestive tract tissues caused by the direct and indirect effects of gastroesophageal reflux. PPIs are commonly prescribed in LPR.

A recent study evaluated the efficacy of PPI (morning single daily dose in fasting condition) for the treatment of LPR.


PPIs are Effective and Well-tolerated in Reducing Symptoms of Laryngopharyngeal Reflux


PPI: Proton pump inhibitor, GI: Gastrointestinal, LPR: Laryngopharyngeal reflux, RSI: Reflux Symptom Index.


Pizzorni, N., Ambrogi, F., Eplite, A. et al. Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux:
a non-inferiority randomized controlled trial. Eur Arch Otorhinolaryngol 279, 2533–2542 (2022).