Respiratory
High Prevalence of Respiratory Symptoms after COVID-19 is Associated with Disease Severity Markers
According to a latest study published in the ‘Nature Journal of Scientific Reports’, higher prevalence of respiratory symptoms, impaired diffusion capacity of lungs and persistent chest computerized tomography (CT) findings after 3 months of hospital admission for COVID-19, were associated with high viral load, low antibody levels, and high levels of matrix metalloproteinase (MMP)-9 during admission.
This study was a multicentric, randomized, open-labelled clinical trial which collected data from 108 hospitalized COVID-19 patients along with a 3-month follow-up, to evaluate associations between clinical characteristics during hospital admission and respiratory outcomes after 3 months of hospitalization.
The key results were as follows:
- High antibody levels at baseline showed a positive effect on pulmonary function.
- Low levels of IgG antibodies to SARS-CoV-2 seemed to predict reduced diffusion capacity of lungs at 3 months.
- High plasma levels of MMP-9, both during hospital stay and 3 months after hospitalisation, were associated with signs of both reversible and irreversible changes on chest CT.
In conclusion, the results of the study suggested that baseline clinical characteristics of COVID-19 at the time of hospital admission can predict pulmonary outcomes in later stages following hospitalization for COVID-19.
Lerum, T.V., Maltzahn, N.N., Aukrust, P. et al. Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9. Sci Rep 11, 23205 (2021). https://www.nature.com/articles/s41598-021-02547-x Accessed on 9 December, 2021.
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