Respiratory
The IISc Finds A Novel Inhibitory Action of Montelukast Against the SARS-CoV-2 Virus
Montelukast administration lead to significantly fewer events of clinical deterioration in hospitalized COVID-19 patients and repurposing Montelukast for tackling cytokine storms in COVID-19 patients has been suggested. A recent study by the Indian Institute of Science (IISc) investigated the anti-viral activity of several FDA approved agents including Montelukast against the SARS-CoV-2 virus.
Newer evidence coming from IISc suggests that Montelukast can be used as a lead molecule to design potent inhibitors against SARS-CoV-2.
SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2, IISc: Indian Institute of Science, COVID-19: Coronavirus disease 2019, From the Makers of:
Nsp1: Non-structural protein 1.
Afsar M, Narayan R, Akhtar MN, Das D, Rahil H, Nagaraj SK, Eswarappa SM, Tripathi S, Hussain T. Drug targeting Nsp1-ribosomal
complex shows antiviral activity against SARS-CoV-2. Elife. 2022 Mar 24;11:e74877.
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